NanoPass’s MicronJetTM technology offers a significant edge over current methods of intradermal delivery with its high consistency, low leakage rate and high success rate evaluated by bleb/wheal formation5-7. Its microscopic size makes it less intimidating, reduces pain and as a result is preferred by a majority of subjects1,8,9.
Sharper and more robust than regular needles, the NanoPass MicronJetTM microneedles are based on MEMS (Micro Electro Mechanical Systems) technology and are made of pure silicon crystal. Not to be confused with silicone oil or rubber, the silicon crystal is one of earth’s pure chemical elements known for its robustness and biocompatibility. The utilization of MEMS technology with a thick-walled, patent protected, pyramid design has enabled the creation of elaborate miniature devices with unprecedented mechanical stability and structural precision.
NanoPass currently produces hollow microneedles for intradermal
injection and can produce solid micro-projections on demand
Frequently Asked Questions
Q. What should I do in case of leakage?
A. Follow the common practice as with a regular needle and syringe
Q. What are the main causes of major leakage?
A. Injection may have started out wet – avoid pressing the plunger prior to injection
A. Syringe not held properly – make sure you hold the syringe flanges between fingers and thumb (see figure No. 2); avoid switching hands
A. Improper device orientation – make sure blue line faces you during injection and syringe is not tilted sideways or rotated (see figure No. 2)
A. Too high / low injection angle – make sure angle between syringe axis and skin surface is as close as possible to 45˚
A. Insufficient pressure applied to the skin – increase slightly
A. Skin not stretched – make sure to keep the skin stretched throughout the entire injection
Q. What are the causes of small/no bleb without leakage?
A. Large air bubble within syringe – make sure to fill syringe properly and remove air bubbles
A. The fluid is leaking between the device and the syringe – make sure you firmly connect the device to the syringe
Q. What are the causes of high injection pressure?
A. Too much pressure is applied to the skin – reduce slightly
A. Improper injection angle – too high. Make sure angle between syringe axis and skin surface is as close as possible to 45˚
A. Skin type or texture – try different injection site
Intradermal vaccination is safe.
Over the years, intradermal vaccination has been proved to be very safe with only minor adverse effects. Studies have found that intradermal vaccination may be associated with a greater incidence of local reactogenicity that typically resolves quickly. Adverse events primarily include local mild pain, swelling, and redness, but no systemic reactions*
For adverse events and contraindications and Warnings and precautions please see MicronJetTM Instruction For Use
*Marra F, Young F et al. meta-analysis of intradermal versus intramuscular influenza vaccines: immunogenicity and adverse events. Influenza
Other Respir Viruses 2013; 7:584-603;