Hollow microneedles for intradermal injection
Intradermal vaccine delivery has been repeatedly shown to allow significant dose sparing when compared to conventional administration methods such as intramuscular and subcutaneous administration. The dermis and epidermis of the human skin are rich in antigen-presenting cells, such as Langerhans cells and dendritic cells, which play a critical role in the induction of immune responses. Injection of vaccines into these layers delivers antigens closer to these cells thus smaller doses of antigen might induce an equivalent immune response to the standard dose*.
NanoPass MicronJet technology offers a significant edge over current methods of intradermal delivery with its high consistency, low leakage rate and high success rate evaluated by bleb/wheal formation5-7. Its microscopic size makes it less intimidating, reduces pain and as a result is preferred by a majority of subjects1,8,9.
Sharper than regular needles, the NanoPass MicronJet microneedles are based on MEMS (Micro Electro Mechanical Systems) technology and are made of pure silicon crystal.
Not to be confused with silicone oil or rubber, the silicon crystal is one of earth’s pure chemical elements known for its robustness and biocompatibility . The utilization of MEMS technology with thick-walled pyramid design has enabled the creation of elaborate miniature devices with unprecedented mechanical stability and structural precision.
NanoPass currently produces hollow microneedles for intradermal
injection and can produce solid micro-projections on demand
*Darin Zehrung et al. Intradermal delivery for vaccine dose sparing: Overview of current issues. Vaccine 31 (2013) 3392– 3395